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Princeton, NJ, 28 November, 2023 ─ iQure Pharma Inc, (iQure) a trailblazing pre-clinical drug discovery company focusing on central nervous system (CNS) disorders, announce the successful second closing of its Series A financing round. This oversubscribed investment brings the company's total Series A capital to $1.8 million, a significant increase from the initial close of $1.2 million.


The second close of this round was spearheaded by Mass Medical Angels, a Boston-based investor group with deep expertise in early-stage life science and med-tech companies.

iQure's leading compound, iQ-007, is a neuromodulator targeting toxic levels of glutamate in the synaptic cleft. An elevated level of glutamate leads to neurotoxicity and ultimately to neural degeneration. iQ-007 operates by a Positive Allosteric Modulation of Excitatory Amino Acid Transporter 2 (EAAT2 PAM), which is responsible for up to 90% of glutamate uptake. The company’s pioneering glutamate clearance platform is expected to foster the development of new treatments for a wide range of neuro disorders, including epilepsy, stroke, neuropathic pain, Parkinson’s, Alzheimer’s, and Traumatic Brain Injury. These treatments are aimed at delivering effective solutions without the common side-effects associated with CNS therapeutics.


The Company is targeting clinical development of iQ-007 in 2024. This milestone will mark a significant step forward in the company's commitment to revolutionizing CNS healthcare.

Pawel Zolnierczyk, iQure CEO: “The oversubscription of our Series A round, led by experienced life science investors Mass Medical Angels, validates iQure Pharma’s innovative approach to glutamate clearance. We remain dedicated to our mission of improving lives of patients living with neurological conditions.”


For further information, please contact pawel.zolnierczyk@iqurepharma.com.


About iQure Pharma:

iQure Pharma, a global biotech firm headquartered in the US, is focused on the development of new therapeutics for CNS, including neuropathic pain, epilepsy and other neurodegenerative diseases. iQure researchers, clinicians, and pharmaceutical professionals work closely with academic partners, industry experts, and patient organizations to build medically and socially beneficial therapies based on a revolutionary glutamate-clearance platform for treating neurodegenerative conditions including neuro-inflammation.


About Mass Medical Angels:

Mass Medical Angels (MA2) is a seed stage investor group focused exclusively on life science and healthcare investments. Its mission is to bring more tools to clinicians while attaining superior returns for our investors. To do this, we provide financing and mentoring to early-stage life-science companies to help them obtain further funding, reach positive cash-flows, and get acquired. MA2 members are carefully vetted for deep experience in the health sciences and include both physicians and executives from successful startups and major life science companies. Teams of members conduct extensive diligence before advising the group on a prospective investment. MA2 invests in medical devices, therapeutics, diagnostics, health services, health information technologies, and relevant research-related tools including laboratory equipment.

Princeton, NJ, October 11, 2023 ─ iQure Pharma Inc. (iQure), a CNS company dedicated to the development of new epilepsy and pain management therapeutics, has completed the first closing of its latest round of funding.


The company has raised $1.2M to progress with IND-enabling pivotal tox studies for its lead asset iQ-007, a first in class EAAT2 PAM neuromodulator. iQ-007 is a novel therapeutic candidate to treat epilepsy and other neurodegenerative conditions.


The round was led by Munich-based life science fund Ventura BioMed Investors and anchor early-stage med-tech investor OKG Capital. Both investors see this round as a first step towards further funding to complete preclinical development and start Phase 1 trials.


iQure's leading compound, iQ-007, is a neuromodulator targeting toxic levels of glutamate in the synaptic cleft. An elevated level of glutamate leads to neurotoxicity and ultimately to neural degeneration. iQ-007 operates by a Positive Allosteric Modulation of Excitatory Amino Acid Transporter 2 (EAAT2 PAM), which is responsible for up to 90% of glutamate uptake. A decrease in EAAT2 function is observed in epilepsy, stroke, Alzheimer's disease, neuropathic pain and ALS. Preclinical in vivo efficacy and safety data strongly support the potential value of this compound for patients suffering from epilepsy, including those who have seen limited success with seizure control using existing medications. iQ-007 has successfully completed the prestigious NIH ETSP epilepsy screening program and pivotal tox studies are ongoing. The Company is looking to start clinical development of iQ-007 in 2024.


Pawel Zolnierczyk, iQure CEO: “Addressing neurodegeneration and preventing seizures in an effective and safe manner is a critical medical and social need. Epilepsy alone affects over 50M people worldwide and approximately 30% of them struggle to control their seizures using current medication. Many also suffer from reduced quality of life due to medication side effects. In addition, aging populations are contributing to a surge in neurodegenerative diseases such as Alzheimer's and Parkinson's, with over 55M people currently suffering from dementia and 10M new cases identified every year. Securing funding from life science focused investors Ventura BioMed Investors and OKG Capital is a major milestone and will accelerate our clinical development. We also want to thank leading global CNS researcher Prof Krzysztof Kaminski and Jagiellonian University in Poland, who are instrumental in the ongoing development of iQ-007, for their close and successful collaboration. We are looking forward to bringing iQ-007 to clinical development in 2024.”


About iQure Pharma

iQure Pharma, a global biotech firm headquartered in the US, is focused on the development of new therapeutics for CNS, including neuropathic pain, epilepsy and other neurodegenerative diseases. iQure researchers, clinicians, and pharmaceutical professionals work closely with academic partners, industry experts, and patient organizations to build medically and socially beneficial therapies.


About Ventura BioMed Investors

Ventura BioMed Investors invest in early-stage life science companies developing pioneering technologies and innovative therapies. As serial entrepreneurs with many years of experience, we help shape the long- term development of our portfolio companies and provide them access to our broad investor and business network. Ventura BioMed Investors supports exceptional entrepreneurs with their vision to accelerate medical breakthroughs that solve unmet patient needs.


About OKG Capital

OKG Capital is a specialist med-tech and life science investor based in the US with operations in London and Geneva. OKG invests in the management and diagnosis of serious chronic diseases affecting individuals and burdening healthcare systems. OKG aims to bridge the gap between cutting edge science and clinical practice, operating at the intersection between patient need and long-term financial return.

Princeton, NJ, September 5, 2023 ─ iQure Pharma Inc. (iQure), a company dedicated to the development of new epilepsy and pain management therapeutics, is proud to announce that its lead asset, iQ-007, has been accepted into the prestigious NIH PSPP (part of the NIH HEAL Initiative) program to identify and profile non-addictive therapeutics for pain.


iQ-007 is a positive allosteric modulator of the EAAT2 transporter and represents a novel approach to treat neurodegenerative diseases. iQ-007 showed efficacy in pain models and has successfully completed the NIH ETSP (Epilepsy Therapy Screening Program) , which focuses on new therapies for drug resistant epilepsy. The acceptance of iQ-007 into the PSPP program is another confirmation of the importance of glutamate management in neurodegenerative diseases and the role iQ-007 can play in the treatment of different indications. “With its excellent profile in epilepsy, we are confident that iQ-007 can also play an important role in the treatment of neuropathic pain. Experimental results from the NIH PSPP program will add to the existing data and contribute significantly to iQ-007’s profile for alleviating neuropathic pain.” said Chief Executive Officer, Pawel Zolnierczyk,


The PSPP program provides a fully NIH-funded, stepwise testing approach, including an assessment of in vitro binding studies and pharmacokinetic profiles, side effect profiles, abuse liability, and efficacy in models relevant to human pain conditions.


About iQure Pharma

iQure Pharma, a global biotech firm headquartered in the US, is focused on the development of new therapeutics for CNS, including neuropathic pain, epilepsy and other neurodegenerative diseases. iQure researchers, clinicians, and pharmaceutical professionals work closely with academic partners, industry experts, and patient organizations to build medically and socially beneficial therapies. For more information about supporting iQure’s initiatives, contact iQure CEO Pawel Zolnierczyk at pawel.zolnierczyk@iqurepharma.com.

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